abstract：:Primary sclerosing cholangitis (PSC), a chronic inflammatory process affecting the extrahepatic and/or medium to large bile ducts, is not rare in children. It has features suggesting an autoimmune pathogenesis, although the mechanism of tissue damage remains unknown. The clinical presentation of childhood primary scle...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts EA

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:We designed an animal model in order to clarify whether Helicobacter pylori infection causes the gastric mucosal lesion frequently seen in cirrhotic patients. METHODS:Ammonia (NH3) solution was given to rats with carbon tetrachloride-induced cirrhosis. The gastric mucosal hexosamine (Hx) content and histopa...

journal_title：Journal of gastroenterology and hepatology

authors： Sugimoto M,Machida Y,Ito K

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Changes in neutrophil functions in obstructive jaundice have been poorly understood. An in vitro experimental study was performed to evaluate the effect of obstructive jaundice on the functions of macrophages (secretion of neutrophil chemoattractants) and neutrophils (chemotaxis and superoxide anion...

journal_title：Journal of gastroenterology and hepatology

authors： Tsuji K,Kubota Y,Yamamoto S,Yanagitani K,Amoh Y,Takaoka M,Ogura M,Kin H,Inoue K

更新日期：1999-05-01 00:00:00

abstract：:This article highlights the importance of hepatotropic viruses as pathogens in patients undergoing transplantation, their contribution to morbidity and mortality after transplantation and the approach to treatment of these pathogens when they cause disease. Although many advances have been made in the management of vi...

journal_title：Journal of gastroenterology and hepatology

authors： Bzowej NH,Wright TL

更新日期：1999-05-01 00:00:00

abstract：:Hepatitis B virus (HBV) affects more than 300 million individuals worldwide and in the United States approximately 1.25 million individuals are chronic carriers of HBV. The risk of becoming a chronic hepatitis B virus surface antigen carrier is dependent upon the mode of acquisition of infection as well as the age of ...

journal_title：Journal of gastroenterology and hepatology

authors： Imperial JC

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Data on anorectal physiology in patients with disordered thyroid metabolism are lacking. This prospective study was performed to evaluate anorectal physiology in patients with either hyperthyroidism and diarrhoea, or hypothyroidism and constipation in order to assess slow transit in hypothyroid patients. ME...

journal_title：Journal of gastroenterology and hepatology

authors： Deen KI,Seneviratne SL,de Silva HJ

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Studies of eradication of Helicobacter pylori and subsequent resolution of H. pylori-related gastritis, have focused mainly on medium and long-term change following eradication therapies. Results from those studies have shown that both acute and chronic inflammatory changes found in gastric mucosa eventually...

journal_title：Journal of gastroenterology and hepatology

authors： Chen W,Shu D,Wilson IR,Tie A,Chadwick VS

更新日期：1999-04-01 00:00:00

abstract：:Here we identify a previously unreported cause of rectal bleeding (juvenile polyposis) in a patient with cystic fibrosis (CF). We believe this patient most likely has two coexisting genetic diseases. It also raises many issues about organ transplantation in a patient with medical conditions that individually increase ...

journal_title：Journal of gastroenterology and hepatology

authors： Treepongkaruna S,Hardikar W,Chow CW,Smith AL,Oliver MR

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:In order to evaluate the prophylactic impact of sclerotherapy of small varices in patients with cirrhosis and no endoscopic signs suggesting risk of haemorrhage, a randomized clinical trial was performed. METHODS:Seventy-one hospitalized patients met the inclusion criteria of diagnosis of cirrhosis with no ...

journal_title：Journal of gastroenterology and hepatology

authors： Strauss E,Ribeiro MF,Albano A,Honain NZ,Maffei RA Jr,Caly WR

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Haemosuccus pancreaticus is a rare complication of pancreatitis. It is a diagnostic problem for even the most astute clinician and a challenge for the expert endoscopist. We report a 25-year-old male patient who had all the features usually seen in haemosuccus pancreaticus patients: recurrent obscure upper g...

journal_title：Journal of gastroenterology and hepatology

authors： Yattoo GN,Khuroo MS,Wani NA,Wani KA,Bhat FA

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether the amount of Helicobacter pylori and the extent of gastric metaplasia in the duodenal mucosa play critical roles in the pathogenesis of duodenal ulcer. METHODS:Duodenal and gastric biopsy specimens were obtained from H. pylori-positive patients with duodenal u...

journal_title：Journal of gastroenterology and hepatology

authors： Futami H,Takashima M,Furuta T,Hanai H,Kaneko E

更新日期：1999-02-01 00:00:00

abstract：:Flexible sigmoidoscopy has been recommended as a screening method to reduce the incidence of colorectal cancer in asymptomatic, average-risk subjects through the early detection and removal of polyps. However, the association between distal and proximal colonic neoplasia and, hence, the requirement for colonoscopic fo...

journal_title：Journal of gastroenterology and hepatology

authors： Collett JA,Platell C,Fletcher DR,Aquilia S,Olynyk JK

更新日期：1999-01-01 00:00:00

abstract：:In order to identify proguanylin-secreting cells, we have raised an antiserum against the synthetic fragment of human proguanylin (1-15) and have examined the proguanylin-positive cells in the human and rat gastrointestinal tract by immunohistochemical methods. Numerous proguanylin (1-15)-immunoreactive cells were fou...

journal_title：Journal of gastroenterology and hepatology

authors： Ieda H,Naruse S,Furuya S,Ozaki T,Ando E,Nokihara K,Hori S,Kitagawa M,Hayakawa T

更新日期：1998-12-01 00:00:00

abstract：:It was recently reported that mutations in the precore and core promoter region of hepatitis B virus (HBV) are associated with fulminant hepatitis. The aim of this study was to investigate the association of mutations in the precore and core promoter region of HBV with fulminant and severe acute hepatitis. We studied ...

journal_title：Journal of gastroenterology and hepatology

authors： Aritomi T,Yatsuhashi H,Fujino T,Yamasaki K,Inoue O,Koga M,Kato Y,Yano M

更新日期：1998-11-01 00:00:00

abstract：:To study the replicative efficiency and pathogenicity of hepatitis B virus precore variant (A1896), anti-hepatitis B virus e antigen (HBe) titre was studied in naturally occurring wild-type virus infection, A1896 variant infection and dual infection. Higher titre of anti-HBe was found in patients with no virus replica...

journal_title：Journal of gastroenterology and hepatology

authors： Wen YM,Ma ZM,Tu G,Zhai WR,He LF,Yao X

更新日期：1998-11-01 00:00:00

abstract：:Infection by verocytotoxin-producing Escherichia coli (VTEC) is prevalent in many parts of the world but relatively uncommon in Asia, except Japan. A territory wide screening for VTEC (April to August 1996) in diarrhoeal stool samples sent to six hospital microbiology laboratories in Hong Kong revealed only four isola...

journal_title：Journal of gastroenterology and hepatology

authors： Wong S,Yam WC,Leung P,Woo P,Yuen KY

更新日期：1998-11-01 00:00:00

abstract：:We examined whether a single inoculation of Helicobacter pylori can colonize the stomachs of ulcerated rats and delay their healing and whether an antibiotic drug and acid pump inhibitors can enhance the ulcer healing in infected rats. Ulcers were produced by a submucosal injection of acetic acid solution into the gas...

journal_title：Journal of gastroenterology and hepatology

authors： Li T,Okabe S

更新日期：1998-11-01 00:00:00

abstract：:Advances in technology have made possible the clinical application of magnetic resonance cholangiography, endoscopic, intra-operative and laparoscopic ultrasound in the study of the biliary tree, in addition to conventional magnetic resonance imaging and transabdominal ultrasound. The role of the conventional, as well...

journal_title：Journal of gastroenterology and hepatology

authors： Chan YL

更新日期：1998-11-01 00:00:00

abstract：:Endoscopic injection sclerotherapy (EIS) is known to produce oesophageal structural and motility changes; however, alterations in frequency and severity of gastro-oesophageal reflux (GER) following EIS have not been investigated in detail. We studied 22 patients with cirrhosis and oesophageal varices before EIS and 26...

journal_title：Journal of gastroenterology and hepatology

authors： Ghoshal UC,Saraswat VA,Aggarwal R,Misra A,Dhiman RK,Naik SR

更新日期：1998-10-01 00:00:00

abstract：:The aim of this study was to determine the distribution of hepatitis C virus (HCV) genotypes in Australian patients with hepatitis C and to identify factors associated with particular genotypes. Serum isolates of HCV-RNA were genotyped using a commercial oligonucleotide hybridization (line probe) assay. Relationships ...

journal_title：Journal of gastroenterology and hepatology

authors： Kaba S,Dutta U,Byth K,Crewe EB,Khan MH,Coverdale SA,Lin R,Liddle C,Farrell GC

更新日期：1998-09-01 00:00:00

abstract：:Following partial hepatectomy (PH), there is a rapid and highly orchestrated series of biochemical events which occur prior to cellular proliferation. Some of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress related or required for the co...

journal_title：Journal of gastroenterology and hepatology

authors： Brenner DA

更新日期：1998-09-01 00:00:00

abstract：:Prostaglandin E1 (PGE1) has been reported to have, experimentally and clinically, a protective effect against liver damage. This effect may result from the relaxation of hepatic stellate cells, whose contraction induces vasoconstriction of hepatic sinusoids. However, prostaglandins are unstable and a new drug delivery...

journal_title：Journal of gastroenterology and hepatology

authors： Wang XE,Watanabe S,Oide H,Hirose M,Itatsu T,Osada T,Takazakura Y,Yokoi Y,Sato N

更新日期：1998-09-01 00:00:00

abstract：:Four types of materials, type I collagen coat (Coat), acid-soluble type I collagen gel (Hardgel), pepsin-treated acid-soluble type I collagen gel (Softgel), and an extract of extracellular matrix of the murine Engelbreth-Holm-Swarm sarcoma (Matrigel), were used as matrices to culture rat hepatic parenchymal cells, and...

journal_title：Journal of gastroenterology and hepatology

authors： Awata R,Sawai H,Imai K,Terada K,Senoo H,Sugiyama T

更新日期：1998-09-01 00:00:00

abstract：:Previous research from this laboratory using a continuous enteral ethanol (EtOH) administration model demonstrated that Kupffer cells are pivotal in the development of EtOH-induced liver injury. When Kupffer cells were destroyed using gadolinium chloride (GdCl3 ) or the gut was sterilized with polymyxin B and neomycin...

journal_title：Journal of gastroenterology and hepatology

authors： Thurman RG,Bradford BU,Iimuro Y,Knecht KT,Arteel GE,Yin M,Connor HD,Wall C,Raleigh JA,Frankenberg MV,Adachi Y,Forman DT,Brenner D,Kadiiska M,Mason RP

更新日期：1998-09-01 00:00:00

abstract：:Tuberculosis is known to involve the liver in different ways. The term hepatobiliary tuberculosis refers to the localized form of hepatic tuberculosis as a distinct clinical entity, with signs and symptoms related to the hepatobiliary tract. Its clinical features and the different diagnostic aids used in its diagnosis...

journal_title：Journal of gastroenterology and hepatology

authors： Alvarez SZ

更新日期：1998-08-01 00:00:00

abstract：:This study was designed to elucidate the efficacy of University of Wisconsin (UW) solution for preventing liver injury, when used as a hypothermic perfusate infused into the systemic circulation during extended hepatectomy with hepatic inflow occlusion. Adult mongrel dogs (9.5-17.5 kg, n = 14) were subjected to 75% he...

journal_title：Journal of gastroenterology and hepatology

authors： Ohya T,Ohwada S,Kawashima Y,Tanahashi Y,Takahashi T,Ichikawa H,Tomizawa N,Morishita Y

更新日期：1998-08-01 00:00:00

abstract：:Typhoid fever is often associated with abnormal liver biochemical tests, but severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. There have been more than 150 cases of salmonella hepatitis reported from both developed and developing countries. The documented incidence varies w...

journal_title：Journal of gastroenterology and hepatology

authors： Pramoolsinsap C,Viranuvatti V

更新日期：1998-07-01 00:00:00

abstract：:The production of interleukin-8 (CINC: cytokine-induced neutrophil chemo-attractant) from different cell populations in the rat liver was studied and cells related to the initiation of CINC production in lipopolysaccharide (LPS)-injected endotoxaemic rats were characterized. Sinusoidal endothelial cells (16.4 +/- 10.6...

journal_title：Journal of gastroenterology and hepatology

authors： Ohkubo K,Masumoto T,Horiike N,Onji M

更新日期：1998-07-01 00:00:00

abstract：:Maintaining high levels of intracellular cyclic AMP (cAMP) is known to inhibit the growth of various proliferating cells including hepatocytes. We show here that transient (30 min) elevations of cAMP induced by addition of 8-bromo-cAMP (1 mmol/L) to rat hepatocytes in primary culture at three time points (12 h, 16 h a...

journal_title：Journal of gastroenterology and hepatology

authors： Kikukawa M,Okamoto Y,Nakano H

更新日期：1998-06-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) has been reported to be detectable in about 10% of gastric carcinomas. We performed a comparative study of endosonographic findings of EBV-positive and -negative early gastric carcinomas. Epstein-Barr virus was detected in 11.8% (four of 34) of endosonographically observed early gastric ca...

journal_title：Journal of gastroenterology and hepatology

authors： Nishikawa J,Yanai H,Mizugaki Y,Takada K,Tada M,Okita K

更新日期：1998-06-01 00:00:00

abstract：:Helicobacter pylori is present in infected patients not only on the gastric epithelial cell surface but also in gastric mucus. We developed a competitive polymerase chain reaction (cPCR) method for quantitative measurement of H. pylori in gastric mucus. The aim of this study was to determine the number of H. pylori in...

journal_title：Journal of gastroenterology and hepatology

authors： Furuta T,Takashima M,Futami H,Arai H,Hanai H,Kaneko E

更新日期：1998-05-01 00:00:00

abstract：:Antipyrine metabolism is widely used as an index of the drug-metabolizing reserve of the liver. It is well known that metabolism of this drug is impaired in subjects with acute hepatitis or cirrhosis, but conflicting data have been reported regarding patients with chronic postinfectious hepatitis or liver cancer. We s...

journal_title：Journal of gastroenterology and hepatology

authors： Grieco A,Castellano R,Matera A,Marcoccia S,Di Rocco P,Ragazzoni E,Vecchio FM,Gasbarrini G

更新日期：1998-05-01 00:00:00

abstract：:Cell proliferation in the gastroduodenal mucosa of patients with duodenal ulcers was evaluated using flow cytometry. Forty patients with duodenal ulcers and 12 normal subjects were investigated. Biopsy samples were obtained during endoscopic examination and subjected to DNA analysis by flow cytometry. Thirty patients ...

journal_title：Journal of gastroenterology and hepatology

authors： Kobayashi I,Kawano S,Tsuji S,Nakama A,Sawaoka H,Masuda E,Nagano K,Fusamoto H,Kamada T

更新日期：1998-04-01 00:00:00

abstract：:The liver is an active site for the biosynthesis of haem and porphyrinogens/porphyrins, which are intermediates of the haem biosynthetic pathway, because haem is required for functional activity of the cytochrome P 450 system and other critical hepatic haemoproteins. The production of hepatic haem is regulated primari...

journal_title：Journal of gastroenterology and hepatology

authors： Bloomer JR

更新日期：1998-03-01 00:00:00

abstract：:Ki-67 expression in tumours has been shown to be associated with prognosis in patients with hepatocellular carcinoma (HCC). In this study, primary HCC samples were obtained from 67 patients undergoing surgical resection. None of these patients had been subjected previously to any other form of therapy, such as arteria...

journal_title：Journal of gastroenterology and hepatology

authors： King KL,Hwang JJ,Chau GY,Tsay SH,Chi CW,Lee TG,Wu LH,Wu CW,Lui WY

更新日期：1998-03-01 00:00:00

abstract：:A frequent association of biliary tract carcinoma and anomalous pancreaticobiliary ductal union (APBD) is well recognized, especially gall-bladder carcinoma in undilated type APBD. However, little is known about the presence and incidence of adenomyomatosis (AMT) of the gall-bladder, a presumed premalignant lesion, in...

journal_title：Journal of gastroenterology and hepatology

authors： Tanno S,Obara T,Maguchi H,Fujii T,Mizukami Y,Shudo R,Takahashi K,Nishino N,Arisato S,Ura H,Kohgo Y

更新日期：1998-02-01 00:00:00

abstract：:The effects of camostat mesilate, a synthetic serine protease inhibitor on gastric microcirculation and active oxygen species generated by leucocytes from the gastric and jugular veins in the early period after thermal injury were assessed. Male Wistar rats were anaesthetized and a 30% full skin-thickness dorsal burn ...

journal_title：Journal of gastroenterology and hepatology

authors： Yoshida M,Wakabayashi G,Ishikawa H,Otani Y,Shimazu M,Kubota T,Kumal K,Kurose I,Miura S,Ishii H,Kitajima M

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to investigate the value of carbon dioxide-enhanced ultrasonography (CO2-US) in the evaluation of viable hepatocellular carcinomas (HCC) which were treated by transcatheter arterial embolization (TAE), percutaneous ethanol injection (PEI), or a combination treatment (TAE and PEI). Forty-o...

journal_title：Journal of gastroenterology and hepatology

authors： Chen RC,Wang CK,Chiang LC,Lo HY,Duh SJ,Chen WT,Tu HY,Liao LY,Wang CS,Chen PH

更新日期：1998-01-01 00:00:00

abstract：:Acute cholangitis is associated with significant morbidity and mortality. Endoscopic drainage procedures have been shown to be a safe and effective mode of treatment in acute cholangitis. As there is paucity of large series on endoscopic management of acute cholangitis, a study was performed to evaluate safety and eff...

journal_title：Journal of gastroenterology and hepatology

authors： Sharma BC,Agarwal DK,Baijal SS,Saraswat VA,Choudhuri G,Naik SR

更新日期：1997-12-01 00:00:00

abstract：:Infiltrating leucocytes are activated to generate reactive oxygen species or to produce several molecules in inflamed colonic mucosa. To clarify the phenotypical and functional properties of activating cells in colitic mucosa, 23 patients with ulcerative colitis and 13 controls were studied using a combined method for...

journal_title：Journal of gastroenterology and hepatology

authors： Oshitani N,Sawa Y,Hara J,Adachi K,Nakamura S,Matsumoto T,Arakawa T,Kuroki T

更新日期：1997-12-01 00:00:00